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ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 3
Exploring the correlation between ibuprofen solubility and permeability in intestinal disease conditions
Mustafa Sinan KAYNAK 1 Murat SOYSEVEN 2 Berna KAVAL 3 Mustafa ÇELEBIER 4 Emrah AYGEYIK 5 Selma ŞAHIN 6 Göksel ARLI 2-7
1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 26470, Eskişehir, Türkiye
2 Anadolu University, Yunus Emre Vocational School of Health Services, Department of Medical Services and Techniques, 26470, Eskişehir, Türkiye
3 Muğla Sıktı Koçman University, Vocational School of Health Services, Program in Pharmacy Services, Muğla, Türkiye
4 Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Türkiye
5 Yozgat Bozok University, Science and Technology Application and Research Center, Yozgat, Türkiye
6 Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Ankara, Türkiye
7 Anadolu Univerity, Faculty of Pharmacy, Department of Analytical Chemistry, 26470, Eskişehir, Türkiye
DOI : 10.23893/1307-2080.APS6238 In this study, physicochemical properties of Ibuprofen were evaluated using HPLC-DAD system to examine the effect of pH on the solubility and intestinal permeability of Ibuprofen. Ibuprofen is still one of the most used and safest non-selective NSAIDs among those approved. Ibuprofen solubility is dramatically affected by pH changes. There is not enough data to show if pH dependent water solubility of ibuprofen will affect its absorption/bioavailability. For this purpose, lipophilicity parameters (logkw) of ibuprofen were determined at various pH ranges using HPLC-DAD system and the results were compared with invivo intestinal permeability results obtained where a perfusion medium having different pH values used (pH 3.9, 4.9 and pH 7.4). The results confirmed that the acidic pH of the perfusion medium increased the permeability of ibuprofen, but in basic pH values (pH 7.4) the permeability was relatively lower. The permeability results were in correlation with determined lipophilicity. Keywords : Ibuprofen, intestinal permeability, HPLC diffusion coefficient, acid dissociation constant, drug absorption

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