| Acceptance rate | 46% |
|---|---|
| Time to first decision | 20 days* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 2
Natural polymers for targeted drug delivery to the colon: A comparative study of tamarind gum and karaya gum
1 L. J. Institute of Pharmacy, LJ University, Ahmedabad-382210, India2 Research Scholar, Gujarat Technological University, Ahmedabad, India
DOI : 10.23893/1307-2080.APS6222 The study aimed to create an effective colon-targeted budesonide delivery system using natural polymers. Various natural gums were assessed for their ability to develop a microbial degradation-based colon-targeted drug delivery system. The sensitivity of polymers to colonic enzymes was tested by evaluating viscosity changes in the presence of a prebiotic culture medium simulating rat cecal content. Tamarind gum and Karaya gum exhibited superior viscometric profiles. Compression coating with these gums, followed by an Eudragit S 100 coat, was employed for successful colon delivery. A 32-factorial design optimized the system, using variables like polymer to ethyl cellulose (EC) ratio and Eudragit S 100 weight gain. The design-space stipulated less than 10% drug release in 2 hours (h), less than 15% in 5 h, and over 50% in 7 h for colon targeting. The Tamarind gum batch (TM 9) released 8.91% at 5 h and 50.23% at 7 h, achieving optimal drug delivery to the colon. Keywords : budesonide, tamarind gum, karaya gum, Eudragit S 100, colon targeting