ACTA Pharmaceutica Sciencia
2006 , Vol 48 , Num 2
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N4-BENZOYL-N1-DIHYDROXY-BENZOYLTHIOSEMICARBAZIDES AND THEIR CYCLIC 1,3,4-THIADIAZOLE DERIVATIVES
Department of Medicinal Chemistry and Pharmacognosy, Department of Pharmaceutical Technology, Irbid, Jordan
Two series of compounds have been synthesized and tested for their antimicrobial activity using the broth macrodilution method. Series I included N4-benzoyl-N1-dihydroxybenzoylthiosemicarbazides (3a-e) and series II included 2-benzoylamino-5-(dihydroxyphenyl)-1,3,4-thiadiazoles (4a-e) the later of which showed selectivity against Staphylococcus aureus. The most potent compound from series I was the parent compound 1 (N4-benzoyl-N1-2,5-dihydroxybenzoylthiosemicarbazide), while the most potent member in series II was compound 4c (2-benzoylamino-5-(2,6-dihydroxyphenyl)-1,3,4-thiadiazole).
Keywords :
ANTIBACTERIAL, THIOSEMICARBAZIDE, THIADIAZOLE, DIHYDROZYBENZOIC ACID HYDRAZIDES