Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*approximate number of days


ACTA Pharmaceutica Sciencia 2006 , Vol 48 , Num 2
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N4-BENZOYL-N1-DIHYDROXY-BENZOYLTHIOSEMICARBAZIDES AND THEIR CYCLIC 1,3,4-THIADIAZOLE DERIVATIVES
AMJAD M QANDİL, HAİTHAM N TUMAH, MOHAMMAD A HASSAN
Department of Medicinal Chemistry and Pharmacognosy, Department of Pharmaceutical Technology, Irbid, Jordan Two series of compounds have been synthesized and tested for their antimicrobial activity using the broth macrodilution method. Series I included N4-benzoyl-N1-dihydroxybenzoylthiosemicarbazides (3a-e) and series II included 2-benzoylamino-5-(dihydroxyphenyl)-1,3,4-thiadiazoles (4a-e) the later of which showed selectivity against Staphylococcus aureus. The most potent compound from series I was the parent compound 1 (N4-benzoyl-N1-2,5-dihydroxybenzoylthiosemicarbazide), while the most potent member in series II was compound 4c (2-benzoylamino-5-(2,6-dihydroxyphenyl)-1,3,4-thiadiazole). Keywords : ANTIBACTERIAL, THIOSEMICARBAZIDE, THIADIAZOLE, DIHYDROZYBENZOIC ACID HYDRAZIDES

Istanbul Medipol University