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ACTA Pharmaceutica Sciencia 2023 , Vol 61 , Num 3
Assessment of compressional, mechanical and release properties of Terminalia randii gum in paracetamol tablet formulation
Oluyemisi A. BAMIRO 1 Lateef G. BAKRE 1 Olutayo A. ADELEYE 2
1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Nigeria
2 Department of Pharmaceutics and Pharmaceutical Technology, Federal University Oye-Ekiti, Ekiti State, Nigeria
DOI : 10.23893/1307-2080.APS6121 Paracetamol tablets were formulated with Terminalia randii gum as a binder at varying concentrations (1-10%, w/w) and the compressional characteristics was compared with polyvinyl pyrrolidone (PVP). The compressional properties were evaluated using density measurements, Heckel and Kawakita equations. The mechanical properties were evaluated using friability, crushing strength, and crushing strength-friability ratio (CSFR), while the release properties were studied using disintegration time, dissolution time and Kitazawa equations. Formulations containing Terminalia gum showed faster onset of plastic deformation with a lower total amount of plastic deformation. The crushing strength and release properties of the formulations increased, while friability decreased, with increase in binder concentration. Formulations containing PVP had better mechanical properties as seen in the high CSFR values. Formulations produced with Terminalia gum produced tablets with slower dissolution. This study shows that the onset of plastic deformation was faster, but the total amount of plastic deformation was lower in formulations containing Terminalia gum. Keywords : Terminalia randii gum, compressional characteristics, Heckel equation, Kawakita equation

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