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ACTA Pharmaceutica Sciencia
2023 , Vol 61 , Num 3
Biological activity and chemical composition of the essential oil from the fruits of Ferula rigidula Fisch. ex DC.
1 Anadolu University, Faculty of Pharmacy, Department of Pharmacognosy, Eskisehir, Türkiye2 Istanbul Medipol University, School of Pharmacy, Department of Pharmacognosy, Istanbul, Türkiye
3 Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6117 Viewed : 9333 - Downloaded : 2834 The hydro-distilled essential oils of the fruits of F. rigidula Fisch. ex DC. was analyzed by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS) systems at the same time. Thirty-one compounds were characterized representing 98.2% of the essential oils. The main components of the oil were determined as a-pinene and camphene (24% and 20%, respectively). The anticandidal and antibacterial effects of the essential oil were determined by using partly modified CLSI protocols M27-A2 and M7-A7, respectively. The essential oil of the dried fruits showed several inhibitory effects on the tested bacteria panel (MIC, 62.5 to 2000 µg/mL) and Candida species (MIC, 125 to 1000 µg/mL). Keywords : Antibacterial; anticandidal; Ferula rigidula ;essential oil; GCMS