| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2023 , Vol 61 , Num 2
Syzygium aromaticum essential oil ameliorates levofloxacin-induced hepatic injury in rats: antioxidant, biomarker and histopathological analysis
1 Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Indonesia2 Laboratory of Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Indonesia
3 Department of Pulmonology, Faculty of Medicine, Hasanuddin University, Indonesia
DOI : 10.23893/1307-2080.APS6113 Viewed : 9664 - Downloaded : 3286 Prolonged levofloxacin treatment can trigger hepatotoxicity. This study aimed to examine Syzygium aromaticum L. essential oil effect on levofloxacin-induced hepatic injury in rats. The chemical constituents and radical scavenging activity were also examined. Rats (n=30) were grouped to receive per oral administration of either placebo, levofloxacin (93 mg/kg), S. aromaticum L. oil (10, 25, or 50 mg/kg), or curcuma (6 mg/kg) with levofloxacin for 28 days. Serum liver biomarkers, liver malondialdehyde (MDA) levels, and histopathological changes were analyzed. S. aromaticum L. oil contained eugenol (63.63%) and the IC50 was 35.1 µg/mL. Levofloxacin induced significant increases in serum biomarker and tissue MDA levels (p < 0.05), with significant damage in hepatocytes. The oil treatment (10 mg/kg) reduced the levels of alanine aminotransferase, total bilirubin, lactate dehydrogenase, tissue MDA (p < 0.05), and the hepatic injury. In conclusion, S. aromaticum L. oil alleviated levofloxacin-induced liver injury, possibly related to its eugenol content and radical scavenging activity. Keywords : Clove essential oil, hepatotoxicity, levofloxacin, Syzygium aromaticum L.