ACTA Pharmaceutica Sciencia 2022 , Vol 60 , Num 2
Formulation and Evaluation of Sugar Spheres Containing Antiemetic Drug
1 Department of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Soldevanahalli, Achit Nagar post, Bengaluru- 560107, Karnataka, India
DOI : 10.23893/1307-2080.APS.6011 The aim of the research study was to formulate and evaluate Metoclopramide loaded sugar spheres for oral drug delivery. Sugar spheres were prepared by extrusionspheronization method. Drug-excipients characterization studies were done by FTIR and UV analysis. Formulations were subjected to various evaluation parameters such as particle size, SEM (Scanning Electron Microscopy), drug content and in vitro drug release studies. Anti-emetic study was carried out by using rat model. Surface morphology of sugar spheres by SEM, showed it was spherical. Drug content was found to be 93.7%. The results of in vitro drug release data of the optimized sugar spheres formulation F8 showed drug release up to 98%. From the animal study, it was observed that F8 formulation showed better antiemetic activity. Stability studies were carried out for F8 formulation, revealed that there were no noticeable changes in drug content and in vitro drug release study. Hence, it is suitable candidate for the treatment of emesis, special focus on pediatrics. Keywords : Sugar spheres, metoclopramide, emesis, extrusion-spheronization

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