ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 3
A Niosomal Gel of Cefoperazone Sodium for Topical Application
NAVEEN Kumar R 1 SAYANI Bhattacharyya 1
1 Krupanidhi College of Pharmacy, Department of Pharmaceutics, Bangalore, India
DOI : 10.23893/1307-2080.APS.05929 The present study endeavors to prepare a niosomal gel of Cefoperazone sodium (CFS), as a novel dermal delivery for the treatment of skin infections. CFS loaded niosomes were prepared using different molar ratio of Tween 80 and Cholesterol by ether injection method using experimental design. The optimized formula was evaluated for DSC, XRPD and AFM. A niosomal gel with the optimized formulation was prepared in Carbopol 934 and were evaluated for gelling properties, in-vitro release, ex-vivo permeation and skin irritation study on rats. Quality by design was successfully executed to get stable (Zeta potential -30mV), nano sized (365.3 nm) niosomal vesicles. The niosomal gel of CFS showed a pH around 5.5, and a viscosity of 84.13±0.25 cps, enhanced permeation and no skin irritation. Hence, the study depicts that a superior site-specific delivery of CFS can be achieved with a niosomal gel of the drug in the treatment of skin infections. Keywords : Cefoperazone sodium, custom design, niosomes, niosomal gel, ex-vivo evaluation

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