ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 3
Effect of Seed Oil and Methanol Leaf Extract of Dialium guineense Steud on Wound and Inflammation
Adediwura A FRED-JAIYESIMI 1 Peter A SEGUN 1 Modupe N ADEBOWALE 1 Oluwakemi OGUNLEYE 1 Mary ADESINA 1 Katherine OLUFOLABO O. 1
1 Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus. Ogun State, Nigeria
DOI : 10.23893/1307-2080.APS.05926 Dialium guineense native to the Sub-Saharan Africa serves as a good source of vitamins particularly Vitamin C for children, it is used in folklore medicine as treatment for cough, fever, stomachache, ulcer, wounds and in improving lactation in women. This study aims at investigating the anti-inflammatory and wound healing effects of the crude methanol extract, seed oil, ointments of the extract and seed oil. The phytochemical analysis of the leaf and seed of Dialium guineense were assayed for secondary metabolites. The egg-albumin method was adopted for the anti-inflammatory study while the excision wound model was used to determine the wound healing effect in rats. The presence of Anthraquinones, flavonoids, saponins and sterols were present in the leaf and seed of Dialium guineense. The leaf extract and seed oil of Dialium guineense exhibited anti-inflammatory effect which were not significantly different at the various doses tested (200 mg/kg, 100 mg/kg, 50 mg/kg). The ointment of the leaf extract as well as the seed oil exerted pronounced wound healing effect of 77.8% and 85.7% wound contraction respectively on day 19.The seed oil of Dialium guineense showed a faster wound healing effect than the leaf by creating occlusive effect on the wounds against moisture. Furthermore, the presence of phenolic compounds in the leaf and seed oil exerted a synergistic anti-inflammatory and wound healing effect. Keywords : Dialium guineense, wound healing, anti-inflammatory, seed oil, leaf

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