| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2021 , Vol 59 , Num 3
Stability Indicating Method Development and Validation of Ranolazine Extended Release Tablets
1 Istanbul University, Faculty of Pharmacy, Pharmaceutical Technology Dept., Beyazıt, Istanbul, Turkey2 Biopharma Pharmaceutical, Istanbul, Turkey
DOI : 10.23893/1307-2080.APS.05925 Viewed : 17605 - Downloaded : 5108 The objective of this study was to develop and validate the stability-indicating method for newly developed Extended-Release tablet formulation of Ranolazine. First, new Ranolazine tablet formulation was developed. These tablets were analyzed by using a High-Performance Liquid Chromatography system with a UV detector at 220 nm wavelength and by using C8-3 column (150 mm x 4.6 mm i.d; 5 µm particle size). The injection volume of the system was 10 µl. The validation parameters; Selectivity, linearity, accuracy, robustness, precision and limit of quantification and detection parameters were proved good results. A highly sensitive and simple HPLC-UV analytical method of the Ranolazine tablet formulation was developed in accordance with ICH Guideline Q2 and Q3. Keywords : Ranolazine, HPLC, forced degradation, stability indicating method, validation