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3 weeks |
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ACTA Pharmaceutica Sciencia
2020 , Vol 58 , Num 4
Protective Effect of Trichilia monadelpha (TM) Thonn J.J. de Wilde in Trinitrobenzene Sulfonic Acid Induced Colitis in Rats
1 University of Ibadan, Pharmacology and Therapeutics, Ibadan/Oyo state, NigeriaDOI : 10.23893/1307-2080.APS.05825 Viewed : 18885 - Downloaded : 4966 Trichilia monadelpha (TM) is a plant commonly used to treat gastrointestinal disorders, inflammatory diseases and pain. This study evaluated the effect of aqueousmethanol extract of stem bark of TM (MeTM) on trinitrobenzene sulfonic acid (TNBS) induced rat colitis. Thirty male Wistar rats (180-200 g) were randomly distributed into six groups (n=5): non-colitic, colitic untreated or treated with prednisolone (2 mg/kg) and MeTM (100 ? 400 mg/kg, given orally 2 days pre- and 7 days post-induction). Response to treatment was assessed. GC-MS analysis of MeTM was done.
Prednisolone and MeTM (200 & 400 mg/kg) significantly reduced colonic damage scores, weight/length ratio and MPO activity in colitic rats compared to untreated group (p?0.05). Similarly, MeTM and prednisolone significantly prevented depletion of GSH levels in treated rats compared to untreated colitic rats (p, 0.0001). The most abundant compound is Oleic acid (79%) followed by 6-Octadecanoic acid (3.69%).
Keywords : Trichilia monadelpha, colitis, glutathione, superoxide dismutase, myeloperoxidase