ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 3
PREPARATION AND EVALUATION OF RAMIPRIL NIOSOMES PREPARED USING SONICATION METHOD
NAVİN KUMAR DAHİYA, REKHA RAO, SANJU NANDA
Department of Pharmaceutics, M.M. University, Mullana, Ambala, Haryana, India In present study an attempt was made to formulate ramipril niosomes using Span 40 and Span 60 in combination with cholesterol. According to optical and transmission electron microscopy results, niosomes were found spherical in shape. Particle size distribution analysis showed that ramipril loaded niosomes had a particle size distribution in nm range. In vitro drug release studies indicated that drug release is prolonged when Span 40 and Span 60 surfactant were used as non-ionic surfactants. It was also observed that type of surfactant affects release rate of ramipril. Keywords : NIOSOMES, SPAN 40, SPAN 60

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