ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 2
ENHANCEMENT OF MIOTIC POTENTIAL OF PILOCARPINE BY TAMARIND GUM BASED IN-SITU GELLING OCULAR DOSAGE FORM
GİLHOTRA RİTU MEHRA, MATHUR MANİSH, SAROOT RASHİ, GİLHOTRA NEERAJ, MİSHRA D N
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana-India In-situ gelling solutions are one of the most successful means of delivering the drug at ocular site with maximum bioavailability. Pilocarpine in-situ gelling solution based on alginate along with novel bioadhesive tamarind gum and widely used bioadhesive, chitosan were formulated. The formulations were tested for drug content uniformity, bioadhesive strength, gelation and in vitro release study. Further in-vivo miotic test was carried for all formulations. We found the formulations to be satisfactory in terms of content uniformity, bioadhesion and gelation. The tamarind gum based formulation showed best slow drug release profile compared to the other formulations. It released about 25 % drug in initial hour and about 80 % of the drug was released during the study of 12 h which was slowest then the rest of preparations. In vivo miotic study also showed the most significant long lasting decrease in pupil diameter of rabbits with tamarind gum based formulation. Prolonging the drug action and higher pharmacodynamic action clearly indicates enhancement of pilocarpine bioavailability as compared to conventional eye drop solution. Ocular irritation studies indicated that the formulations were well tolerated and non-irritating. This system may provide an excellent potential alternative ophthalmic sustained-release formulation of pilocarpine for clinical use. Keywords : ALGINATE GLAUCOMA, IN SITU GELLING SOLUTION, PILOCARPINE TAMARIND GUM

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