| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 2
CARBOXYMETHYLCELLULOSE - ALUMINUM HYDROGEL MICROBEADS FOR PROLONGED RELEASE OF SIMVASTATIN
Department of Pharmaceutical Technology, BLDEA's College of Pharmacy, BLDE University, Bijapur, India
Viewed :
18537
-
Downloaded :
6383
Carboxymethylcellulose based hydrogel microbeads loaded with simvastatin were prepared using ionotropic gelation method. The beads were characterized by differential scanning calorimetric (DSC) analysis, and scanning electron microscopy (SEM). DSC studies confirmed the amorphous dispersion of the drug in the hydrogel matrix. The effect of crosslinking agent and polymer concentration on drug release was studied. Increase in concentration of crosslinking agent and polymers decreased the release rate of simvastatin. The release data were fitted to an empirical equation to determine the transport mechanism. Drug release followed anomalous/non-Fickian transport mechanism.
Keywords :
SIMVASTATIN, DRUG RELEASE, HYDROGEL BEADS, CARBOXYMETHYLCELLULOSE