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ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 3
STUDIES ON CRYSTAL FORMS OF GATIFLOXACIN: PREPARATION, CHARACTERIZATION AND DISSOLUTION PROFILE
Department of Pharmaceutics, The Erode College of Pharmacy and Research Institute, Erode, Tamil Nadu, India
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Different crystal forms of Gatifloxacin were prepared using solvents of varying polarity. X-ray diffractometry (XRD), differential scanning calorimetry (DSC), differential thermal analysis (DTA), thermogravimetric analysis (TGA), infrared absorption spectroscopy (FT-IR), melting point, particle size, solubility, and in vitro dissolution rate studies were conducted to investigate various characteristics of different crystalline forms of the gatifloxacin. Three types of polymorphs were identified based on thermal analysis but fails to make any distinction among GATI-I and GATI-III. FT-IR spectral technique and X-ray diffractometry confirmed that existence of four different polymorphs. The polymorphs differed in their solubility and dissolution profile. Crystallization of gatifloxacin from ethanol (GATI-II) produced spongy opaque crystals that exhibited highest solubility and dissolution rate than other crystals due to its lowest melting point and smaller particle size. It is concluded finally that the study has indicated the existence of four polymorphic forms of Gatifloxacin (1).
Keywords :
CRYSTAL FORMS, GATIFLOXACIN, CHARACTERIZATION, THERMAL ANALYSIS, SOLUBILITY, DISSOLUTION