| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2006 , Vol 48 , Num 2
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N4-BENZOYL-N1-DIHYDROXY-BENZOYLTHIOSEMICARBAZIDES AND THEIR CYCLIC 1,3,4-THIADIAZOLE DERIVATIVES
Department of Medicinal Chemistry and Pharmacognosy, Department of Pharmaceutical Technology, Irbid, Jordan
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Two series of compounds have been synthesized and tested for their antimicrobial activity using the broth macrodilution method. Series I included N4-benzoyl-N1-dihydroxybenzoylthiosemicarbazides (3a-e) and series II included 2-benzoylamino-5-(dihydroxyphenyl)-1,3,4-thiadiazoles (4a-e) the later of which showed selectivity against Staphylococcus aureus. The most potent compound from series I was the parent compound 1 (N4-benzoyl-N1-2,5-dihydroxybenzoylthiosemicarbazide), while the most potent member in series II was compound 4c (2-benzoylamino-5-(2,6-dihydroxyphenyl)-1,3,4-thiadiazole).
Keywords :
ANTIBACTERIAL, THIOSEMICARBAZIDE, THIADIAZOLE, DIHYDROZYBENZOIC ACID HYDRAZIDES