| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 2
CARBOXYMETHYLCELLULOSE - ALUMINUM HYDROGEL MICROBEADS FOR PROLONGED RELEASE OF SIMVASTATIN
Department of Pharmaceutical Technology, BLDEA's College of Pharmacy, BLDE University, Bijapur, India
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Carboxymethylcellulose based hydrogel microbeads loaded with simvastatin were prepared using ionotropic gelation method. The beads were characterized by differential scanning calorimetric (DSC) analysis, and scanning electron microscopy (SEM). DSC studies confirmed the amorphous dispersion of the drug in the hydrogel matrix. The effect of crosslinking agent and polymer concentration on drug release was studied. Increase in concentration of crosslinking agent and polymers decreased the release rate of simvastatin. The release data were fitted to an empirical equation to determine the transport mechanism. Drug release followed anomalous/non-Fickian transport mechanism.
Keywords :
SIMVASTATIN, DRUG RELEASE, HYDROGEL BEADS, CARBOXYMETHYLCELLULOSE