| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 3
SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW LAVONYLAZOLE DERIVATIVES
Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara- Turkey
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In this study, a new series of 2-[4’-[1-Azolyl]methyl]phenyl]-4H-benzopyran-4-on(A1-A3,A8) and 2-[3’-[1-Azolyl]methyl]phenyl]-4H-benzopyran-4-on (A4-A7) were synthesized by the reaction of 3’- and 4’-bromomethylflavone with azoles in strong alkaline conditions and some physico-chemical properties are described. The chemical structures of all synthesized compounds have been elucidated by IR, 1H-NMR, mass spectra. Antifungal and antibacterial activities of the compounds were compared with Miconazole and Ampicilline trihydrate.
Keywords :
FLAVONE DERIVATIVES, AZOLES, ANTIMICROBIAL, ANTIFUNGAL ACTIVITIES