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ACTA Pharmaceutica Sciencia
2026 , Vol 64 , Num 1
Protective effects of Telfairia occidentalis (Hook. F) leaf extract against phenylhydrazine-induced hemolytic anemia in Wistar rats
1 University of Ibadan, School of Pharmaceutical Sciences, Department of Pharmacology and Toxicology, Ibadan, Nigeria2 University of Ibadan, School of Basic Medical Sciences, Ibadan, Department of Pharmacology and Therapeutics, Ibadan, Nigeria
3 University of Ibadan, School of Basic Medical Sciences, Department of Anatomy, Ibadan, Nigeria
DOI : 10.23893/1307-2080.APS6407 Viewed : 224 - Downloaded : 114 Anemia is characterized by decreased red blood cells or hemoglobin concentration, resulting in reduced oxygen-carrying capacity. Telfairia occidentalis, a tropical green leafy vegetable, is utilized in ethnomedicine as a hematinic and in the treatment of some illnesses. Thus, this study evaluated the protective effects of Telfairia occidentalis in phenyhyldrazine-induced anemia in Wistar rats. Telfairia occidentalis leaf was extracted in 70% ethanol (TOL). Thirty male Wistar rats were divided into five groups (n=6) and pretreated for 7 days with TOL at doses of 250, 500, or 0.2 mg/kg folic acid. Thereafter, anemia was induced with phenylhydrazine (20 mg/kg) for four days and treatment continued till the 28th day after which the animals were euthanized. Hematological parameters, oxidative stress markers, cytokine levels, as well as liver and kidney function were assessed. Hemolytic anemia induced by phenylhydrazine resulted in alteration in hematological parameters, decreased antioxidant biomarkers (Catalase, GSH), elevated oxidative stress marker (malondialdehyde) as well as elevation of the liver enzymes, urea and creatinine levels. However, treatment with 250 and 500 mg/kg ethanol extract of Telfairia occidentalis significantly ameliorated these alterations. T. occidentalis showed good prophylactic activity against phenylhydrazineinduced anemia and liver and kidney dysfunction. Keywords : Telfairia occidentalis, anemia, phenylhydrazine, hematology