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ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 4
Effects of repeated low and high doses of energy drink on kindling-type seizures, antidepressant and anxiolytic treatment in mice
1 Istanbul Medipol University, School of Pharmacy, Department of Pharmacology, Istanbul, Türkiye2 Başkent University, Faculty of Pharmacy, Department of Pharmacology, Ankara, Türkiye
3 Institute of Drug and Medical Device, Ankara, Türkiye
4 Yeditepe Universiyty, Faculty of Pharmacy, Istanbul, Türkiye
5 Yeditepe University, Faculty of Pharmacy, Department of Medical Pharmacology, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6350 Viewed : 76 - Downloaded : 21 Energy drinks (EDs) may cause neuropsychological risks. This study scrutinized the effects of repeated low and high-dose energy drinks (LED; 4ml/kg and HED; 12ml/kg) exposures on total locomotor activity (TLA), seizure activity, and antidepressant and anxiolytic treatments. 144 female Balb-C mice were randomly divided into three groups (n=48) named seizure, depression, and anxiety. Then, animals were divided into six subgroups. TLA was measured in all groups. While the epileptic activity was tested in intraperitoneally (i.p.) administrated pentylenetetrazole (PTZ)-induced kindling mouse model, depression and anxiety experiments were tested with citalopram (CT) and alprazolam (AL)-pretreated mice. HED decreased the TLA more than the LED group. Seizures in the LED group were higher than in the water drink (WD) group. HED changed depressive outcomes in the HED group. LED and HED altered anxiogenic outcomes in both groups. Conclusively, LED and HED increased the seizure frequency, decreased the success of depression and anxiety treatments. Keywords : anxiety, behavioral changes, depression, energy drink, seizures