| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 2
Preparation and in-vitro evaluation of Paclitaxel-loaded sericin nanoparticles planned for pulmonary drug delivery system
1 University of Al-Turath, School of Pharmacy, Department of Pharmaceutics, Baghdad, Iraq2 University of Baghdad, School of Pharmacy, Department of Pharmaceutics, Baghdad, Iraq
DOI : 10.23893/1307-2080.APS6328 Viewed : 82 - Downloaded : 25 One of the most popular and successful antineoplastic drugs, Paclitaxel (PTX), comes from natural sources and is distinguished by its high lipophilicity. Sericin is a naturally occurring hydrophilic protein which become a popular choice for creating scaffolds for tissue engineering or drug delivery systems using nanocarriers. This work aimed to create and analyze sericin nanoparticles loaded with PTX to deliver lung drugs which synthesized utilizing a desolvation technique and were extensively analyzed to determine their physicochemical features, including particle size, Polydispersity index (PDI), entrapment efficiency, zeta potential, and in vitro drug release profile. Additionally, in vitro aerosolization were conducted to assess the effectiveness of aerosolization and the possibility of delivering drugs to the lungs using PTX-loaded sericin nanoparticles. Cytotoxicity research was performed on these nanoparticles using the A-549 lung cell line. The findings indicated that the sericin nanoparticles loaded with PTX had appropriate particle size, negative zeta potential, high entrapment efficiency, prolonged drug release behavior, and compelling aerosolization features. Moreover, the cytotoxicity assays on cancer cells demonstrated that the sericin nanoparticles loaded with PTX had anticancer solid properties. In conclusion, the PTX-loaded sericin nanoparticles that have been produced show significant potential as an innovative pulmonary drug delivery system for cancer treatment. Keywords : Paclitaxel, sericin, protein nanoparticles, aerosols, pulmonary drug delivery system