| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 2
Serum selenium and manganese levels in obstructive sleep apnea patients and their relationship with GPx and SOD enzyme activities
1 Marmara University, Faculty of Pharmacy, Analytical Chemistry Department, Istanbul, Türkiye2 Marmara University, Institute of Health Sciences, Istanbul, Türkiye
3 Bahçeşehir University, School of Medicine, Department of Biochemistry, Istanbul, Türkiye
4 Hasan Kalyoncu University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Gaziantep, Türkiye
5 Acibadem Altunizade Hospital, Chest Disease Unit, Istanbul, Türkiye
6 Marmara University, Vocational School of Health Services, Department of Medical Laboratory Techniques, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6319 Viewed : 79 - Downloaded : 21 Selenium and manganese are antioxidant elements, are cofactors in the functioning of enzymes. Obstructive sleep apnea (OSA) is the inability to breathe during sleep and may develop due to changes in oxidative stress, antioxidant defense system, and serum trace element levels. Therefore, we aimed to determine the antioxidant enzyme activities glutathione peroxidase (GPx), superoxide dismutase (SOD), as well as Se, Mn levels, in OSA patients (n=38) and healthy controls (n=27). Se and Mn were determined by Graphite Furnace Atomic Absorption Spectrometry (GFAAS), and GPx, SOD enzyme activities were determined by ELISA method in samples taken after polysomnography (PSG). Our results showed that Se, Mn levels in patients were significantly lower than in controls (p<0.0001). GPx activity in patients was lower than in controls (p<0.01), but serum SOD activity was lower than in healthy individuals but not significant (p>0.05). The results showed that the patients" Se, Mn levels, as well as GPx, SOD enzyme activities, were lower than the controls. In conclusion, our study showed that low levels of Se and Mn trace elements in OSA patients are associated with decreased antioxidant enzyme activities and increased oxidative stress. These findings suggest that trace elements affect the antioxidant enzyme activities in which they act as cofactors and that their deficiencies should be eliminated with supportive treatments in OSA patients. Keywords : selenium, manganese, glutathione peroxidase, superoxide dismutase, obstructive sleep apnea