| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 1
Protective benefits of quercetin and lipoic acid on methotrexate-induced oxidative stress in rat spleen
1 Institute of Health Sciences, Marmara University, Istanbul, Türkiye2 Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6315 Viewed : 217 - Downloaded : 55 The study aims to examine the effect of Methotrexate (MTX) treatment on rat spleen and investigate the antioxidant properties of quercetin (Que) and lipoic acid (LA) on MTX. Rats were divided into groups as Controls, MTX-given group, MTX+Que-given group, and MTX+LA-given group. At the end of the experiment, total protein, glutathione (GSH), lipid peroxidation (LPO), nitric oxide (NO), and total sialic acid (SA) levels, also superoxide dismutase (SOD), and catalase activities were determined in spleen homogenates. MTX increased oxidant parameters and both Que and LA effectively decreased LPO, SA, and NO levels. Administration of MTX increased GSH levels and decreased SOD activity, besides Que normalized GSH level and SOD activity, LA decreased GSH activity. Que and LA may be effective in recovering MTX-induced toxicity by decreasing oxidative stress and can be useful in normalizing the damage situation in rat spleen. Keywords : methotrexate, oxidative stress, quercetin, lipoic acid, spleen