| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 1
Development and evaluation of propolis loaded mixed micellar gel: Formulation, optimization and anticancer potential
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Department of Pharmaceutics, Pimpri, Pune, Maharashtra, India2 Sinhgad College of Pharmacy, Department of Pharmaceutical Chemistry, Pune, Maharashtra, India
DOI : 10.23893/1307-2080.APS6301 Viewed : 88 - Downloaded : 45 To increase the effectiveness of the anticancer natural product propolis extract (PE), mixed micellar gel formulation composed of Pluronic F127 and Tween 80 was investigated. Cold technique was used to formulate mixed micellar gel loaded with propolis extract (PE-MMG). 32 factorial design was employed to optimize formulation. PE-MMG was characterized for micellar size, surface morphology, surface charge, drug loading, entrapment, release study and in vitro cytotoxicity. Developed optimized formulation showed desirable formulation characteristics Optimized formulation showed desirable characteristics for improved therapeutic performance. Enhanced cytotoxicity potential revealed through MTT Assay by PE-MMG as compared with PE showed enhanced permeability and chemosensitization. In overall developed formulation further studied as a promising carrier for cancer therapy. Keywords : mixed micellar gel, propolis, Pluronic F127, Tween 80, MCF 7