| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 4
In vivo antidiarrheal and in vitro antimicrobial activities of the aerial part extracts of Waronia saharae Benthem ex Benth. & Coss.
1 Mohammed First University, Department of Biology, Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, 60 000 Oujda, Morocco2 Çukurova University, Institute of Natural and Applied Sciences, Department of Biotechnology, 01330 Balcalı/Sarıçam, Adana, Türkiye
3 Chouaib Doukkali University, Faculty of Sciences, Department of Biology, Nutritional Physiopathology, Neurosciences and Toxicology Team, Laboratory of Anthropogenetic, Biotechnology and Health, 24000, El Jadida, Morocco
4 Sidi Mohamed Ben Abdallah University, Faculty of Sciences Dhar El Mehraz, Laboratory of Physiology, Pharmacology and Environmental Health, BP 1796 Atlas, 30 000 Fez, Morocco
5 Regional Center for Professions of Education and Training, Oriental Region, 60000 Oujda, Morocco
DOI : 10.23893/1307-2080.APS6255 Viewed : 143 - Downloaded : 51 A North African endemic plant known as Warionia saharae Benth. & Coss is frequently used in Morocco for treating digestive problems. In this work, the possible in vivo antidiarrheal effect of the aqueous extract of aerial part of this plant was evaluated to confirm its traditional use, also, the organic fractions were tested in vitro on antimicrobial activity. The results obtained from the in vivo study of the antidiarrheal activity of the aqueous extract showed significant inhibition against the diarrheal effect induced by castor oil with 75.07% at a 400 mg/kg dose. Additionally, this extract significantly inhibited the amount of fluid that accumulated in the intestinal lumen with 38.45% at 400 mg/kg, as well as the intestinal transit of activated charcoal. The antibacterial activities were tested for the aqueous extract and four organic fractions against five strains for the Gram-negative and the Gram-positive bacteria. Also, these extracts were tested for antifungal activity. The results of the study reveal that the aqueous extract and the dichloromethane fraction demonstrated the greatest levels of activity against the tested bacteria. This work provides a possible strategy for treating bacterial infections, which can be used to take advantage of this antimicrobial activities promising in the treatment of diarrhea caused primarily by these bacteria. Keywords : Warionia saharae, antidiarrheal effect, antibacterial effect, antifungal effect