Acceptance rate 46%
Time to first decision 6 months*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 4
The comparison between the results of turbidimetric method for C-Reactive Protein measurement using different instruments
Erkan UCA 1 Neziha HACIHASANOĞLU ÇAKMAK 2 Türkan YİĞİTBAŞI 3
1 Istanbul Medipol University, Institute of Health Sciences, Istanbul, Türkiye
2 Istanbul Medipol University, Vocational School of Health Services, Medical Laboratory Techniques, Istanbul, Türkiye
3 Istanbul Medipol University, School of Medicine, Department of Basic Medical Sciences, Department of Medical Biochemistry, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6251 Viewed : 497 - Downloaded : 121 C-reactive protein (CRP) is considered a marker of chronic inflammation and also a mediator of the atherosclerotic process. The purpose of this study is to compare the results of three quantitative immunoturbidimetric method used to measure CRP amounts in patient serum samples in a clinical laboratory. Freshly collected patient serums (n=100) were analyzed with 2 different analyzer (Siemens Advia 1800 and Abbott Architect C 8000) and 3 different reagents (Siemens, Sentinel, Archem). In order to determine whether they provide equivalent results in terms of traceability, the EP09-A3 guideline was used, and comparisons were evaluated within the scope of this standard. Limit of quantification (LoQ), Inter27 assay, Intra-assay, precision studies have been done. The relationship between these three reagents was determined by regression analysis and Bland Altman method. Regression coefficiencies between these three methods were found: Archem- Sentinel r2=0,9987, Archem ? Siemens r2=0,9986 and Sentinel ? Siemens r2=0,9984. Regression equations between Archem-Sentinel y= - 0,1359+1.0035x, between Archem- Siemens y= -0,02646+1,002x and between Sentinel ? Siemens y=0,1326+0,9978x were found. For the first time in the literature, our results indicated that these three immunoturbidimetric methods were compatible. Keywords : Siemens, sentinel, archem, CRP, method comparison

Istanbul Medipol University