| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 4
Effect of kaempferol, amygdalin and methylprednisolone alone and in combination in induced cytokine storm in mice
1 Al-Nahrain University, College of Medicine, Department of Pharmacology and Therapeutics, Baghdad, IraqDOI : 10.23893/1307-2080.APS6248 Viewed : 153 - Downloaded : 36 Cytokine storm can cause organ failure and even death in severe cases. There is ongoing research into developing drugs that can target cytokines and modulate the immune response to prevent or treat cytokine storm for that reason the present study aimed to evaluate the effect of kaempferol, amygdalin and methylprednisolone alone and in combination for their potential effectiveness in managing cytokine storm in a study including the collection of blood samples from groups included an apparently healthy, negative control, positive control and ten other groups of prophylaxis and treatment with methylprednisolone, kaempferol, amygdalin either alone or in combination to measure interleukin -1?, 6, 8 (IL-1?, 6, 8) and tumor necrosis factor- ? (TNF-?) which demonstrated that in comparison with controls, the blood levels of IL-1, IL-6, IL-8, and TNF-? were significantly higher in the Lipopolysaccharide (LPS) group which decreased by using the studied drugs either alone or in combination for one hour before or after LPS induction which demonstrated that natural compounds such as amygdalin, and kaempferol have shown promise in reducing the levels of pro-inflammatory cytokines and may have therapeutic potential for the treatment of chronic inflammatory diseases. Keywords : amygdalin, cytokine storm, kaempferol, methylprednisolone