| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 3
Thermosensitive gel of pomegranate peel extract as alternative for the treatment of local infections
1 Bilecik Seyh Edebali University, Vocational School of Health Services, Department of Pharmacy Services, Bilecik, Türkiye2 Bilecik Seyh Edebali University, Faculty of Engineering, Department of Bioengineering, Bilecik, Türkiye
3 Bilecik Seyh Edebali University, Graduate School of Education, Department of Biotechnology, Bilecik, Türkiye
4 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskisehir, Türkiye
DOI : 10.23893/1307-2080.APS6241 Studies on the use of herbal extracts in the treatment of local diseases are increasing day by day. To maintain activity of extract and provide convenient usage, ideal formulation must be developed for extracts. In this study, we aimed to develop thermosensitive gel of pomegranate peel extract and investigate its antimicrobial activity. The total phenolic content and antioxidant capacity of extract was found 397.00 ± 9.36 mg GAE/100 g, and 10750.00 ± 132.29 mg TE/100 g respectively. The gelation temperature of thermosensitive was measured as 25.3 ± 1.5?C. The developed gel formulation showed antimicrobial activity against Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans as similar with extract. As a result, the developed thermosensitive gel formulation of pomegranate peel extract could be an alternative for the treatment of local infections by its ease of usage and efficacy in future clinical trials after detailed characterization. Keywords : pomegranate peel, extract, thermosensitive gel, antimicrobial activity