| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 3
The assessment of the antimicrobial effect of gemfibrozil alone or in combination with ceftriaxone or gentamycin on several types of bacteria
1 Mustansiriyah University, College of Dentistry, Department of Pharmacology, Iraq2 Al-Hilla University College, Department of Pharmacy, Babylon, Iraq
DOI : 10.23893/1307-2080.APS6235 The present work aimed to investigate the potential antimicrobial action of gemfibrozil alone and in combination with ceftriaxone or gentamycin against specific bacterial strains isolates (S. aureus, S. epidermidis, Streptococcus spp., and E. coli) with an evaluation of minimum inhibitory concentration (MIC) values, which revealed that gemfibrozil demonstrated the lowest MIC values against all studied bacterial isolates and the combination of gemfibrozil with either ceftriaxone or gentamycin results in an improvement in the MIC values to levels lower than those obtained with ceftriaxone or gentamycin alone, which revealed that there is a synergistic effect of the gemfibrozil combination with ceftriaxone or gentamycin on antibacterial activity against the studied pathogens, which appear more pronouncedly in the effect of combined antibacterial effect upon Staphylococcus aureus, Staphylococcus epidermis, and Streptococcus spp. In conclusion, the current study demonstrated a synergistic effect between gemfibrozil and both ceftriaxone and gentamycin, indicating that the combination of these compounds is a potential therapeutic option for treating resistant bacterial strains. Keywords : ceftriaxone, gemfibrozil, gentamycin, synergism