| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2009 , Vol 51 , Num 3
EFFECTS OF STERILIZATION TECHNIQUES ON THE PEGYLATED POLY (?-BENZYL-L-GLUTAMATE) (PBLG) NANOPARTICLES
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Nanoparticles were prepared by nanoprecipitation technique using poly (?-benzyl-L-glutamate) (PBLG) derivatives. Injectable nanoparticles were assessed for their in vitro properties such as particle size, polydispersity index, zeta potential and surface properties. The possibilities of sterilizing PBLG nanoparticle suspensions by membrane filtration or autoclaving were evaluated. It was found that among these techniques, sterilization with membrane filtration seemed to be the most appropriate technique with any significant effect on in vitro and surface properties. Sterility was assessed on the final product according to pharmacopoeial requirements. Sterility testing results showed no microbial contamination indicating that sterile nanoparticle formulations have been achieved after membrane filtration.
Keywords :
POLY (?-BENZYL-L-GLUTAMATE), PEGYLATED NANOPARTICLES, MEMBRANE FILTRATION, AUTOCLAVING, STERILITY TESTING