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ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 3
Predictive value of lipid profile in predicting the resistance to insulin in apparently healthy adults
Sara Haider KHALID 1 Zainab Hassan HASHIM 1 Qasim Sharhan AL-MAYAH 2 Hisham AL-MATUBSI 3
1 Al-Nahrain University, College of Pharmacy, Department of Pharmacology and Toxicology, Baghdad, Iraq
2 Al-Nahrain University, College of Medicine, Medical Research Unit, Baghdad, Iraq
3 University of Petra, Faculty of Pharmacy and Medical Sciences, Department of Pharmacology and Medical Science, Amman, Jordan
DOI : 10.23893/1307-2080.APS6243 Insulin resistance (IR) progression can lead to the development of metabolic syndrome and type 2 diabetes mellitus. Objective of the current work was to elucidate how useful lipid profile components were in predicting IR in healthy individuals in cross-sectional study conducted on 100 euglycemic, non-diabetic adults (aged ? 45 years). All individuals had their triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), cholesterol, fasting blood sugar (FBS), fasting insulin and glycosylated hemoglobin (HbA1c) levels tested. The predictive values of lipid profile components separately or as ratios, as well as two obesity-related indicators: lipid accumulation products and visceral adiposity index, were evaluated in relation to the HOMA-IR using the receiver operating characteristic (ROC) curve. Results revealed that thirty (30%) of 100 apparently healthy subjects developed IR. The triglycerides/high density lipoprotein (TG/HDL) ratio had the best predictive value with an area under the curve (AUC) of 0.728, 95% CI = 0.617-0.838, p<0.001. The test had 77% sensitivity and 67% specificity, respectively. The optimal TG/HDL ratio cutoff value was 2.96, suggesting that among healthy adults, the TG/HDL ratio might be utilized as a routine screening test to detect IR. Keywords : insulin resistance, lipid profile, homeostasis model assessment, healthy adults

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