| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 2
Effects of tadalafil on vancomycin-induced nephrotoxicity in rats
1 Medico-legal Directorate, MOH, Laboratories Department, Baghdad, Iraq2 Department of Pharmacology, College of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq
DOI : 10.23893/1307-2080.APS6220 Viewed : 5779 - Downloaded : 1708 Tadalafil (TAD) is a member of the Phosphodiesterase 5 (PDE 5) inhibitors used to treat erectile dysfunction. However, recent evidence suggests that it has beneficial nephroprotective effects via a variety of mechanisms. The aim of the present study was to investigate the protective effect of TAD against vancomycin (VAN) - induced nephrotoxicity in rats (n=24), which divided into three groups; model control group that received intraperitoneal VAN, TAD group that received oral TAD and intraperitoneal VAN and normal healthy group. TAD group demonstrated a significant decrease in serum levels of renal function biomarkers and a significant increase in creatinine clearance level compared to the model control group. Furthermore, it showed a significant reduction in the renal levels of malondialdehyde (MDA), neutrophil gelatinase-associated lipocalin (NGAL), and TNF-? with a significant elevation in the renal level of glutathione (GSH) compared to the model control group. Histologically, TAD group showed a significant reduction in renal tissue injury that prove its nephroprotective effect due to its antioxidant and anti-inflammatory properties. Keywords : oxidative stress, nephrotoxicity, tadalafil, vancomycin