Acceptance rate 46%
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Time to decision with review 50 days*

*Approximate number of days

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ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 2
Effects of tadalafil on vancomycin-induced nephrotoxicity in rats
Hassanen A. ABDULAMEER 1 Adeeb A. AL-ZUBAIDY 2
1 Medico-legal Directorate, MOH, Laboratories Department, Baghdad, Iraq
2 Department of Pharmacology, College of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq
DOI : 10.23893/1307-2080.APS6220 Tadalafil (TAD) is a member of the Phosphodiesterase 5 (PDE 5) inhibitors used to treat erectile dysfunction. However, recent evidence suggests that it has beneficial nephroprotective effects via a variety of mechanisms. The aim of the present study was to investigate the protective effect of TAD against vancomycin (VAN) - induced nephrotoxicity in rats (n=24), which divided into three groups; model control group that received intraperitoneal VAN, TAD group that received oral TAD and intraperitoneal VAN and normal healthy group. TAD group demonstrated a significant decrease in serum levels of renal function biomarkers and a significant increase in creatinine clearance level compared to the model control group. Furthermore, it showed a significant reduction in the renal levels of malondialdehyde (MDA), neutrophil gelatinase-associated lipocalin (NGAL), and TNF-? with a significant elevation in the renal level of glutathione (GSH) compared to the model control group. Histologically, TAD group showed a significant reduction in renal tissue injury that prove its nephroprotective effect due to its antioxidant and anti-inflammatory properties. Keywords : oxidative stress, nephrotoxicity, tadalafil, vancomycin

Istanbul Medipol University