| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 2
Evaluation of fluconazole-loaded nanocellulose-reinforced xanthan gum film for drug delivery applications
1 Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, India2 Amity Institute of Pharmacy, Amity University, Noida-201303, Uttar Pradesh, India
DOI : 10.23893/1307-2080.APS6227 Viewed : 5913 - Downloaded : 1708 The purpose of the present study is to prepare xanthan films reinforced with nanocellulose and to evaluate them for drug delivery applications using fluconazole as the model drug. The preparation of films by solvent casting method was optimized using a central composite design. It was observed that increasing the concentration of nanocellulose and polyethylene glycol 4000 increases the tensile strength and delays the release of fluconazole from xanthan gum films. The optimal formulation was composed of nanocellulose (100 mg), polyethylene glycol 4000 (50 mg), and xanthan gum (100 mg) which exhibited the tensile strength of 4220 mN and 100% release of the drug over 24 h. The film had a fibrous surface. The film released fluconazole by zero-order kinetics by super case II transport mechanism. It can be concluded based on the present study that reinforcement of nanocellulose in xanthan gum films improves their tensile strength and imparts sustained release character. Keywords : fluconazole, nanocellulose, film, xanthan gum, sustained drug delivery