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ACTA Pharmaceutica Sciencia
2006 , Vol 48 , Num 1
DESIGN AND EVALUATION OF DICLOFENAC SODIUM OPHTHALMIC INSERTS
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore-4, India
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Diclofenac sodium ophthalmic inserts were prepared by using methyl cellulose (MC), sodium carboxymethyl cellulose (SCMC) alone and in combination. Weight variation, thickness, drug content, ocular irritation and stability of medicated inserts were evaluated. In vitro study was carried out by using a semipermeable dialysis membrane. According to the results, 97 % of drug was released from the formulation containing 4% SCMC and 1% MC in combination over a period of 12 h. Release followed zero order kinetics. Medicated inserts were subjected to UV irradiation and in-vivo drug release studies. No significant change was observed in the drug content and physical features during storage at 30°C and 40°C for 2 months. From this study it was concluded that ophthalmic inserts prepared with 4% SCMC and 1% MC in combination showed sustained release and were found to be stable.
Keywords :
DICLOFENAC SODIUM, OCUSERTS, IN VITRO, IN VIVO EVALUATION