Acceptance rate 46%
Time to first decision 6 months*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.

ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 2
Chemical composition and biological activities of seed butter extracted from Garcinia gummi-gutta (L.) Roxb.
Neenthamadathil Mohandas KRISHNAKUMAR 1 George SHINEY 2
1 Department of Biosciences, Rajagiri College of Social Sciences (Autonomous), Rajagiri P. O., Kalamassery, Cochin, 683104, Kerala, India
2 Department of Biotechnology, Presentation College of Applied Sciences, Puthenvelikkara, Ernakulam, 683594, Kerala, India
DOI : 10.23893/1307-2080.APS6225 Garcinia gummi-gutta (L.) Roxb. is a commercially viable fruit crop and it is a rich source of valuable edible fat known as seed butter. In the present study, the cytotoxic, antiproliferative and antimicrobial properties of G. gummigutta seed butter (GGSB) were investigated. The cytotoxic effects of the seed butter were assessed with Dalton"s Lymphoma Ascites (DLA) and Ehrlich"s Ascites Carcinoma (EAC) cell lines, and also on normal splenocytes. The seed butter was found to be cytotoxic for DLA an EAC and it exhibited a dose dependent effect and IC50 value of 289.04 ?g/mL and 299.18 ?g/mL for DLA and EAC respectively while less toxic to normal spleen cells. Further, human triple negative breast cancer (MDA-MB-231) and hepatocellular carcinoma (HepG2) cell lines in culture exhibited reduction in cell viability revealing its antiproliferative effect. The IC50 value of GGSB against MDA-MB-321 and HepG2 were determined as 66.70±2.60 ?g/mL and 110.98 ?g/mL respectively. The antimicrobial effect of the seed butter was determined by broth dilution method. The gas chromatography mass spectrometry (GC-MS) and gas chromatography with flame ionization detection (GC-FID) analysis revealed the presence fatty acids as the major phytochemical compounds responsible its bioactivities. Keywords : garcinia gummi-gutta, cytotoxicity, antiproliferative effect, antimicrobial activity

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