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ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 1
In vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide
Rengin BAYDAR 1 Ayşe Esra KARADAĞ 1 Sevde Nur BİLTEKİN 2 Etil GÜZELMERİÇ 3 Fatih DEMİRCİ 4
1 Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, 34810 Istanbul, Türkiye
2 Department of Pharmaceutical Microbiology, School of Pharmacy, Istanbul Medipol University, 34810 Istanbul, Türkiye
3 Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755 Istanbul, Türkiye
4 Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Türkiye
DOI : 10.23893/1307-2080.APS6212 Tanacetum parthenium L. (Feverfew) is daisy-like Asteraceae plant carrying sesquiterpene lactones; used for the treatment of migraine and anti-inflammatory effect. This study aims to evaluate T. parthenium extract and major metabolite parthenolide for in vitro COX-1/COX-2, LOX inhibitory activity. The extract analyzed by HPTLC. To evaluate COX-1/COX-2 inhibition assays, studied with commercial kits (20µg/mL concentration for extract, 5 µg/mL for parthenolide). The major component of extract characterized as parthenolide. IC50 values for COX-1/COX-2 inhibition of extract were 10.45 and 9.81µg/mL, for parthenolide; 4.86 and 1.90µg/mL. SI values of T. parthenium extract and parthenolide were 0.93 and 0.39. Extract showed selective COX-2 inhibitory activity. The inhibition value of extract on LOX was 80% and inhibition value of parthenolide was 41.13%. The results suggested that T. parthenium extract showed selective potential for COX-2 enzyme inhibition. To the best of our knowledge, the extract was tested with COX-1, COX-2, and LOX enzymes for the first time. Keywords : COX, LOX, anti-inflammatory, Tanacetum parthenium, feverfew

Istanbul Medipol University