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ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 1
Physical/Chemical modifications of Oryza glaberrima and Digitaria exilis starches: Effect on packing and compression properties of ibuprofen tablet formulations
Omobolanle Ayoyinka OMOTESO 1 Michael Ayodele ODENIYI 1
1 Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan Nigeria
DOI : 10.23893/1307-2080.APS6208 Imported grain starches are in high demand but are expensive, and their supply is unreliable. To address the need for innovative formulators, the development and use of native starches or the synthesis of modified starches with predetermined functions from locally sourced underused plants as excipients in pharmaceutical industries is critical. The primary goal of this research is to explore the influence of physical and chemical modification on the compressional and packing features of dual blends of Ibuprofen with Oryza glaberrima and Digitaria exilis starches in oral tablet formulation. Different ratios of starches and Ibuprofen were used in the direct compression method to prepare the tablets. From the native starch forms, pregelatinized and carboxymethylated starches were produced. The manufactured tablets" compressional features were investigated using the Heckel, Gurham, and Kawakita equations, as well as density measurements. Pregelatinization resulted in a faster onset but a lower amount of plastic deformations than native and carboxymethylated starch formulations. Increasing the particle size of these starches substantially impacts densification, rearrangement of particles, fragmentation propensity, and elastic/plastic deformation. The modified starches would make acceptable excipients because they increased tablet densification compared to the native forms. Keywords : carboxymethylation, compressional properties, direct compression, pregelatinization, starch

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