| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2005 , Vol 47 , Num 3
SYNTHESIS AND EVALUATION OF ANTIMICROBIAL, CYTOTOXIC, AND GENOTOXIC ACTIVITIES OF SUBSTITUTED CYCLOALKANEPYRAZOLES
Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan, Irbid
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A number of 1-substituted-3-methyl-4, 5, 6, 7-tetrahydrocyclohexapyrazoles derivatives, and 1-substituted-3-methyl-4, 5, 6, 7-tetrahydrocyclopentapyrazoles derivatives were synthesized and characterized. These compounds were evaluated for their in vitro antimicrobial, cytotoxic, and mutagenic activities. The results of the biological activities showed that both compound 3c and 3d exhibited antibacterial and antifungal activities. They showed activity against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa, whereas compound 3d was active against Staphylococcus aureus, Enterococcus faecalis. They also showed activity against Candida albicans, Zygosaccharomyces rouxii, and Aspergillus niger. Compound 3c was the most active as antifungal agent. None of the tested compounds found to have mutagenic or cytotoxic action.
Keywords :
SUBSTITUTED CYCLOALKANEPYRAZOLES, SYNTHESIS, ANTIMICROBIAL, CYTOTOXICITY, MUTAGENICITY