| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2023 , Vol 61 , Num 3
Chemical composition, antimicrobial and antioxidant activity of a "lipid phase" from Zanthoxylum pistaciifolium Griseb leaves
1 Pharmacy Department, Faculty of Natural and Exact Sciences, Oriente University, Avenue Patricio Lumumba s/n, 90500 Santiago de Cuba, Cuba2 Medical Toxicology Centre (TOXIMED), Medical Sciences University, Highway km 1½, CP 90400. Santiago de Cuba, Cuba
3 Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium
DOI : 10.23893/1307-2080.APS6118 Viewed : 6950 - Downloaded : 1815 The present research aimed is to carry out the phytochemical analysis and to evaluate the antimicrobial and antioxidant activity, of the lipid phase from Cuban endemic plant Zanthoxylum pistaciifolium Griseb leaves. The total extract was fractioned by Column Chromatography, while its lipid fractions were analyzed by Nuclear Magnetic Resonance and Gas Chromatography-Mass Spectrometry. Antimicrobial activity versus a strain panel of two bacteria and six yeast was tested by microdilution method. Antioxidant activity was evaluated as the scavenging property on DPPH· and ABTS·+ radicals. For the first time 31 compounds are informed, among which fatty acid derivatives and sesquiterpenes prevail. Ethyl palmitate and geranyllinalool emerge as the main compounds. Good anti-Candida activity as well as a moderate radical scavenging property were demonstrated. The cell viability determined reflects a slight toxicity over Vero cells (IC50 in 34.9 ± 0.78 ?g/mL). The investigation reveals that lipid phase has an interesting potential for pharmaceutical applications. Keywords : Antimicrobial activity, ethyl palmitate, gas chromatography-mass spectrometry, geranyllinalool, radical scavenging