| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2023 , Vol 61 , Num 1
JNK and p53 inhibition in regenerationcompetent cells of nerve tissue: a novel approach for treatment of ethanol-induced neurodegeneration
1 Russian Academy of Sciences, Tomsk National Research Medical Center, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, RussiaDOI : 10.23893/1307-2080.APS6104 Viewed : 8428 - Downloaded : 2558 This study aimed to explore the involvement of JNK and p53 in the implementation of nervous tissue regeneration-competent cell functions in ethanol-induced neurodegeneration. The studies were conducted on the C57B1/6 mice. Ethanol-induced neurodegeneration was modeled in vitro and in vivo. The effects of the JNK and p53 inhibitors on the colony-forming capacity of NSC and neuronal-committed progenitors, their proliferative activity and intensity of specialization, as well as the neurotrophin secretion by astrocytes, oligodendrocytes, and microglial cells, were studied. The stimulating role of JNK and p53 in the mitotic activity and specialization of intact NSCs was shown. Inversion of the role of these signaling molecules in the regulation of NSC proliferation in ethanol-induced neurodegeneration has been revealed. It has been found that JNK and p53 are not involved in regulating the NCP functions. The ambiguous role of JNK and p53 in the production of neurotrophic growth factors by neuroglia. Increased secretion of neurotrophins by oligodendrocytes and microglia during the JNK and p53 blockage in the conditions of alcohol exposure was found. These results show the potential for using JNK or p53 inhibitors as novel effective drugs for alcohol encephalopathy therapy. Keywords : Neural stem cells, neuroglia, JNK, p53, neurodegenerative diseases