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ACTA Pharmaceutica Sciencia
2005 , Vol 47 , Num 3
FORMULATION AND EVALUATION OF CONTROLLED RELEASE DILTIAZEM PELLETS USING EUDRAGIT NE40
Department of Pharmacy, Islamia University, Bahawalpur-Pakistan
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A release controlling film coat around diltiazem pellets was developed with Eudrgit NE40 and the effects of percent drug layering, pH and stirring speed of dissolution media on drug release were also evaluated. Diltiazem HCL aqueous solutions were applied onto inert pellets to produce drug pellets, which were subsequently coated with aqueous polymer dispersion using bottom spray Fluidized-bed coater. Coated pellets were cured at 37°C for 24 h. The release profile of coated pellets was found to be inversely proportional to the thickness of the polymer coat and desirable controlled release characteristics could be achieved by manipulating the coating levels. The percent drug layering onto inert pellets had no effect on the release rate of coated pellets. Moreover, diltiazem HCL release was fairly independent of pH and stirring speed.
Keywords :
CONTROLLED RELEASE PELLETS, COATING, EUDRAGIT, DILTIAZEM, FLUIDIZED-BED