ACTA Pharmaceutica Sciencia 2022 , Vol 60 , Num 4
Grewia asiatica Linn. root extract loaded suspension, microparticulate and nanosuspension dosage form: Fabrication, characterization and anthelmintic evaluation
Tarun Kumar 1 Rimpy Pahwa 2 Munish Ahuja 2
1 Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh 123031 (Haryana), India
2 Drug Delivery Research laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001 (Haryana), India
DOI : 10.23893/1307-2080.APS6024 The current study was planned to formulate the Grewia asiatica Linn. root extract loaded herbal formulation and evaluated its potential for in vitro anthelmintic activity. The root extract of Grewia asiatica Linn. was standardized by HPTLC using quercetin and naringenin, as a marker compound. The extract was formulated into a novel microparticulate and nanosuspension dosage form based on the Eudragit S100. The prepared dosage forms were characterized by particle size, morphology, and in vitro release behavior. Further, the comparative evaluation of dosage form revealed the presence of higher in vitro anthelmintic activity in nanosuspension as compared to conventional suspension and microparticulate dosage form. Keywords : Grewia asiatica; nanosuspension; microparticles; suspension; anthelmintic

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