ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 3
Significance of crude and degummed Citrullus lanatus seed oil on inflammatory cytokines in experimental infection induced by Candida albicans
Victor Onukwube APEH 1 Felicia I. CHUKWUMA 1 Florence Nkechi NWORA 1 Obioma Uzoma NJOKU 1 Fred O. NWODO 1
1 Department of Biochemistry, University of Nigeria, Nsukka
DOI : 10.23893/1307-2080.APS.05922 This study evaluated immunomodulatory and candidacidal properties of Citrullus lanatus seed oil (CLSO) on Candida albicans-infected rat. The immunomodulatory and candidacidal activities of both crude and degummed oil at varied doses were determined using 80 female albino rats, randomised into 10 groups of 8 rats per group based on the days 7 and 14 of study. Delayed hypersensitivity reaction showed a significant increase (p<0.05) in the hind paw oedema of rats treated with crude and degummed oil after 24 hours; however after 48 hour, a significant decrease (p<0.05) in hind paw oedema was observed. However, the CD4 + T-lymphocytes decreased at day 14 when compared with day 7 counterpart. In the same vein, IFN-γ and TNF-α decreased from day 7 to day 14 of the study; while IL-10 and IgA increased from day 7 to day 14 of the study. CLSO does not boost immune system, rather demonstrated anti-inflammatory activities of the oil. Keywords : Candidiasis; CD4 count; cytokines; degummed oil; immunosuppression

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