| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
2 Ahmadu Bello University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Industrial Pharmacy, Zaria, Kaduna State, Nigeria
DOI : 10.23893/1307-2080.APS.05723 Viewed : 15206 - Downloaded : 5148 The objective of the study was to characterize the material attributes of a co-processed excipient and determine its suitability for tableting applications.
A single composite excipient named SGS consisting of tapioca starch (TS), gelatin (GEL) and colloidal silicon dioxide (CSD) was developed by co-processing using the method of co-fusion and its solid-state, powder and mechanical properties evaluated.
Particle morphology revealed spherical shaped particles of SGS with slightly rough surfaces. PXRD was characterized by a halo diffraction pattern consistent with amorphous materials. FT-IR studies demonstrated drug-excipient compatibility. Flow properties of SGS improved in relation to its physical mixture (SGS-PM) and the mechanical properties of SGS was enhanced as a result of co-processing. The outcome of the study demonstrates the suitability of SGS as a tableting excipient.
Keywords : Material attributes, starch, co-processed excipient, tableting