| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
DOI : 10.23893/1307-2080.APS.05703 Viewed : 15734 - Downloaded : 4931 Solid dispersions have been proved to be an effective method for the improvement of solubility and bioavailability of poorly water-soluble drugs. The study was designed to demonstrate the potential of ketoprofen loaded BSA solid dispersions on the solubility & in-vitro release of ketoprofen.
Ketoprofen-BSA solid dispersions were prepared by the freeze-drying method. A 2-factor, 3-level central composite experimental design was used to study the effect of varying concentration of BSA and ketoprofen on drug solubility & in-vitro drug release.
The combined effect of concentration of BSA & ketoprofen on % release and solubility exhibited a linear relationship between independent and dependent variables, suggesting that higher level of BSA & ketoprofen favours the expedited release and solubility.
Bovine serum albumin may be explored as a carrier for the preparation of solid dispersion for the enhancement of solubility and in-vitro drug release of BCS class II drug ketoprofen.
Keywords : Bovine serum albumin, Ketoprofen, Solid dispersion, Lyophilization