| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
2 Moshood Abiola Polytechnic, Ojere, Department of Pharmaceutical Technology, School of Science and Technology, Abeokuta, Nigeria
3 University of Ibadan, Ibadan, Nigeria, Department of Pharmacognosy, Faculty of Pharmacy, Ibadan, Nigeria
DOI : 10.23893/1307-2080.APS.05623 Viewed : 15407 - Downloaded : 4901 Background: The methanol extracts of leaf and flower of P. falcisepala (PFL & PFF) were evaluated for inhibitors of alpha amylase/glucosidase (AGIs) with antioxidant property.
Methods: The total phenolic (TPC)/flavonoid content (TFC), antioxidant and digestive enzymes inhibitory activities of the PFL, PFF and PFF fractions; n-hexane (PFFHex), ethyl acetate (PFFEA), n-butanol (PFFBUT) and aqueous (PFFAQ) were evaluated.
Results: The PFF had higher TPC, TFC, greater antioxidant and digestive enzymes inhibitory activities than PFL. Thus, PFF fractions were further evaluated. The PFFEA had the highest TPC (161.05 ± 6.18 mgGAE/g), TFC (112.54 ± 1.69 mgQE/g), alpha amylase inhibitory activity (38.45 ± 2.50 ?g/mL) than acarbose (258.4 ± 6.37 ?g/mL p< 0.05). In addition, PFFEA showed higher activities in the Fe2+ reducing antioxidant power and alpha glucosidase inhibitory assays.
Conclusion: The promising activity of the flower of P. falcisepala can be further explored in the management of hyperglycaemia and oxidative stress.
Keywords : Alpha amylase, Alpha glucosidase, FRAP, DPPH, Phaulopsis falcisepala