| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2008 , Vol 50 , Num 3
COMPARATIVE STUDIES ON DICLOFENAC SODIUM LOADED ALBUMIN/GELATIN MAGNETIC MICROSPHERES FOR INTRA-ARTERIAL ADMINISTRATION
School of Pharmacy, Faculty of Medical Sciences, University of West Indies, Trinidad
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Magnetite was prepared by oxidation of ferrous sulphate by sodium hydroxide. Diclofenac sodium loaded gelatin and albumin magnetic microspheres were prepared by emulsification/cross-linking by glutaraldehyde using ethylcellulose in chloroform and sesame oil with/without span80 as stabilizing medium. The microspheres were characterized by drug loading, entrapment/encapsulation efficiency, particle size, optical microscopy, magnetite content and in vitro release studies. Sesame oil with span80 was found to yield spherical and compact microspheres. Gelatin magnetic microspheres showed better loading, entrapment, encapsulation, release profile and stability than albumin magnetic microspheres.
Keywords :
GELATIN, ALBUMIN, MAGNETIC MICROSPHERES, MAGNETITE, DICLOFENAC SODIUM