| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2017 , Vol 55 , Num 1
Synthesis and Antimycobacterial Activity Evaluation of Isatin-derived 3- [(4- aryl - 2- thiazolyl])hydrazone]-1H- indol- 2, 3- diones
1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskişehir, Turkey2 Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, 34810, İstanbul, Turkey
3 Anadolu University, Faculty of Science, Department of Biology, 26470, Eskişehir, Turkey
DOI : 10.23893/1307-2080.APS.0554 Viewed : 16179 - Downloaded : 4761 A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2af) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their antituberculosis activity against Mycobacterum tuberculosis H37RV (ATCC 27294). Among them, two compounds 2c and 2d were displayed antitubercular potential two-fold greater than standard drugs. Keywords : Isatin, Indole, Thiazole, Antimycobacterial activity