| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 3
FORMULATION AND EVALUATIONS OF EZETIMIBE NANOPARTICLES PREPARED BY CONTROLLED NANOPRECIPITATION AND TRANSFORMATION INTO SOLID DOSAGE FORM
Department of pharmaceutics, B.S.Patel Pharmacy college,Linch, Gujarat, India
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Amorphous nanoparticles of ezetimibe (EZE), a poorly water-soluble drug, were produced by the controlled nanoprecipitation method without adding any surfactants at room temperature. The effects of different types and quantity of solvent and anti-solvent (water) on the physical state of EZE were investigated. The physical state of the formed nanoparticles was significantly influenced by the nature and quantity of solvent. Decreased particle size (627 nm) was observed in batch containing 5 mL ethanol as a solvent and 40 mL water as a anti-solvent, Morphology of optimized nanoparticles was found to spherical in scanning electron microscopy (SEM) this may be due to introduction of the drug solution to the antisolvent generates high supersaturation. The vacuum dried nanoparticles were transfer in to tablet. The XRD analyses confirmed that the prepared EZE was amorphous nanoparticles. Furthermore, the amorphous EZE nanoparticles exhibited significantly enhanced dissolution property when compared to the marketed product.
Keywords :
EZETIMIBE, NANOPARTICLES, CONTROLLED NANOPRECIPITATION, SURFACTANT